The Tysis stands as one of Warframe's classic secondary weapons, an Infested pistol that has quietly maintained its relevance despite newer additions to the arsenal. First introduced in Update 11.7, this weapon fires explosive darts that debuff targets with a multitude of status ailments, with Corrosive damage being its signature effect. While it may have faded from the spotlight in recent years, the Tysis, and particularly its new Coda variant introduced in the 1999 update, can become devastating tools in the hands of experienced Tenno equipped with endgame mods and Forma. This guide explores how to transform both versions into powerful secondary weapons capable of handling Steel Path content and beyond.

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Acquisition and Crafting Requirements

Players can obtain the standard Tysis by purchasing its blueprint from the in-game marketplace for 30,000 Credits. The weapon requires Mastery Rank 9 to use. For those seeking the upgraded version, the Coda Tysis becomes available after unlocking Hollvania, where players can farm Technocyte Coda Liches. This enhanced variant comes pre-built with a progenitor bonus that adds an additional damage type, eliminating the need for crafting.

Crafting Requirements for Standard Tysis:

  • Neurodes: 2

  • Plastids: 400

  • Nano Spores: 900

  • Polymer Bundle: 100

  • Credit Cost: 30,000

  • Build Time: 24 Hours

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Weapon Statistics and Mechanics

The Tysis operates as a semi-automatic pistol that fires explosive darts which embed into targets before detonating after a short delay. While its base damage appears modest, the weapon's true strength lies in its exceptional 50% base status chance per projectile. Each detonation deals Corrosive damage over three seconds and inherits the base shot's status chance, resulting in massive status application potential.

Comparative Stats Table:

Stat Tysis Coda Tysis
Impact Damage 9 18
Puncture Damage 23 32
Slash Damage 17 26
Corrosive Damage 27 (x3) 59 (x3)
Total Damage 130 253
Critical Chance 3% 13%
Critical Multiplier 1.5x 2x
Magazine Size 11 18
Mastery Requirement MR 9 MR 17

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Build Strategies for Different Content

Status Primer Build (Standard Tysis)

This build requires no Forma investment and focuses on maximizing status application. It becomes particularly effective once players gain access to Galvanized mods, though standard variants work adequately for most content below Steel Path.

Key Mods for Status Build:

  • 🎯 Galvanized Shot - The cornerstone mod that scales damage based on status ailments on target

  • 🔥 Element/Status Hybrid Mods - Frostbite, Scorch, and similar mods for diverse damage types

  • 💥 Multishot Mods - Galvanized Diffusion and Lethal Torrent for increased projectile count

Recommended Elemental Combinations:

  • Viral + Heat - Excellent for most content, combining armor shredding with health scaling

  • Blast - Highly effective due to the weapon's high status application rate

Players should select elements that best counter their target faction's weaknesses for optimal performance.

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Coda Tysis Endgame Build

This specialized build requires 5 Forma (typically 4 V polarities) and leverages the Coda variant's improved critical stats to create a hybrid critical/status weapon capable of handling the game's most challenging content.

Critical Enhancement Strategy:

  • The build achieves 37% critical chance with 4.2x multiplier through modding

  • Arcane Avenger on your Warframe adds 45% critical chance, bringing total to 82%

  • This combination transforms the weapon into a reliable critical hitter

Core Mod Setup:

  • Galvanized Aptitude - Significant damage buff per hit

  • 🔥 Secondary Merciless - Scales damage with kills

  • 💨 Galvanized Diffusion - Essential multishot increase

  • ⚙️ Lethal Torrent - Fire rate and additional multishot

  • 🌡️ Primed Heated Charge + Frostbite - Blast damage combination

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Advanced Tactics and Synergies

The Tysis excels as a status primer that can set up enemies for massive damage from primary weapons or Warframe abilities. Its Corrosive damage naturally strips armor, making it particularly effective against heavily armored targets like Grineer and Corrupted enemies. The weapon's projectile nature requires some leading of targets, but its very high accuracy makes it reliable at medium ranges.

Optimal Use Cases:

  • Debuffing tough bosses and mini-bosses

  • Crowd control through mass status application

  • Armor stripping for squad coordination

  • Hybrid damage dealing with Coda variant

For players who enjoy technical gameplay and strategic weapon combinations, the Tysis offers a unique niche that few other secondaries can match. Its recent upgrade through the Coda variant ensures it remains relevant in Warframe's evolving meta, providing both veteran players and newcomers with a weapon that rewards investment and skillful modding.